Lia Millucci Selected Research

Ochronosis

1/2021	Homogentisic acid induces cytoskeleton and extracellular matrix alteration in alkaptonuric cartilage.
10/2020	Homogentisic acid affects human osteoblastic functionality by oxidative stress and alteration of the Wnt/β-catenin signaling pathway.
1/2019	Homogentisic acid induces morphological and mechanical aberration of ochronotic cartilage in alkaptonuria.
7/2017	Cytoskeleton Aberrations in Alkaptonuric Chondrocytes.
1/2014	Amyloidosis, inflammation, and oxidative stress in the heart of an alkaptonuric patient.
9/2013	Antioxidants inhibit SAA formation and pro-inflammatory cytokine release in a human cell model of alkaptonuria.
9/2012	Biochemical and proteomic characterization of alkaptonuric chondrocytes.
12/2011	Redox-proteomics of the effects of homogentisic acid in an in vitro human serum model of alkaptonuric ochronosis.
10/2010	Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis.

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Lia Millucci Research Topics

Disease

27	Alkaptonuria 01/2022 - 10/2010
10	Amyloidosis 12/2020 - 01/2011
9	Ochronosis 01/2021 - 10/2010
5	Inborn Genetic Diseases (Disease, Hereditary) 01/2022 - 10/2010
5	Inflammation (Inflammations) 12/2020 - 12/2016
4	Rare Diseases (Rare Disease) 01/2021 - 11/2012
2	Disease Progression 11/2019 - 12/2016
2	Joint Diseases (Joint Disease) 05/2017 - 01/2017
2	Rheumatic Diseases (Rheumatism) 12/2016 - 11/2016
2	Metabolic Diseases (Metabolic Disease) 04/2016 - 11/2015
2	Heart Failure 01/2012 - 01/2011
2	Alkaptonuric ochronosis 12/2011 - 10/2010
1	Knee Injuries (Knee Injury) 12/2020
1	Osteoarthritis 12/2020
1	Arthritis (Polyarthritis) 01/2017
1	Wounds and Injuries (Trauma) 11/2016
1	Tyrosinemias (Tyrosinemia) 04/2016
1	Amyloid Plaque 01/2014
1	Rheumatoid Arthritis 01/2014
1	Parkinson Disease (Parkinson's Disease) 11/2012

Drug/Important Bio-Agent (IBA)

19	Homogentisic AcidIBA 01/2022 - 10/2010
18	Homogentisate 1,2-Dioxygenase (Homogentisate 1,2 Dioxygenase)IBA 01/2022 - 10/2010
8	EnzymesIBA 01/2022 - 12/2011
7	Melanins (Melanin)IBA 10/2020 - 10/2010
6	Serum Amyloid A Protein (Serum Amyloid A)IBA 12/2020 - 09/2013
5	Tyrosine (L-Tyrosine)FDA Link 05/2017 - 12/2011
5	Amyloid (Amyloid Fibrils)IBA 02/2017 - 01/2011
3	Biomarkers (Surrogate Marker)IBA 12/2020 - 12/2011
3	Proteins (Proteins, Gene)FDA Link 12/2020 - 02/2017
3	Phenylalanine (L-Phenylalanine)FDA Link 12/2016 - 12/2011
3	AntioxidantsIBA 09/2013 - 10/2010
2	PolymersIBA 01/2019 - 01/2017
2	Congo RedIBA 01/2014 - 11/2012
2	CytokinesIBA 01/2014 - 09/2013
2	Atrial Natriuretic Factor (ANF)IBA 01/2012 - 01/2011
1	Advanced Oxidation Protein Products (AOPP)IBA 12/2020
1	chitotriosidaseIBA 12/2020
1	Acetic Acid (Vinegar)FDA LinkGeneric 07/2017
1	quinone (benzoquinone)IBA 07/2017
1	ProteomeIBA 12/2016
1	Hematoxylin (Haematoxylon)IBA 11/2016
1	Eosine Yellowish-(YS) (Eosin)IBA 11/2016
1	nitisinone (Orfadin)FDA Link 04/2016
1	HerbicidesIBA 04/2016
1	Pharmaceutical PreparationsIBA 04/2016
1	DioxygenasesIBA 04/2016
1	LipidsIBA 01/2014
1	Methotrexate (Mexate)FDA LinkGeneric 11/2012
1	AA amyloidosisIBA 11/2012
1	Sulfhydryl Compounds (Thiols)IBA 12/2011

Therapy/Procedure

2	Therapeutics 09/2013 - 11/2012
1	Replacement Arthroplasty 11/2016